Lab Head: Nick Leslie Institute of Biological Chemistry, Biophysics and Bioengineering

Welcome to the Inositol Lipid Signalling Lab

Cellular signal transduction is the process by which cells coordinate their behaviour in response to their external surroundings including incoming signals, such as hormones and growth factors. The PI 3-kinase/PTEN signalling pathway is a key regulator of cell growth, survival and motility in many cell types and loss of control over its activity is a characteristic of most types of cancer and many other diseases, such as type 2 diabetes. Our work aims to understand in more detail the workings of the proteins that make up the core of this pathway, and the lipid signalling molecules that they synthesise and metabolise. We use a variety of approaches from enzymology, proteomics and lipid biochemistry to functional studies in cultured cells and in vivo.

We also collaborate extensively with bioengineers to apply novel technologies to cancer research.

Recent Events:

Medical Research Scotland have funded a 4yr studentship for us to collaborate with Renishaw and apply 3D bioprinting methods to make improved pre-clinical brain tumour models

Dinesh Kumar joined the lab in October to develop 3D bioprinting methods to make multilineage brain tumour constructs

Amit's paper studying PTEN stability was published in the Journal of Biological Chemistry in July